Although advanced AIDS-KS may show partial response or regrowth (Evans et al, 2002), induction/selection of MDR in KS-derived cells has not yet been examined, although KS spindle cells express the ABC transporters (Schwartsmann et al, 1989; Gupta et al, 1998) and the individual drugs alone from the drug regimen for AIDS-KS (HIV-PIs and anthracyclines) can induce or select cells that express ABCB1. Here, ABCB1 is linked to Kaposi's sarcoma.