EGFR and head and neck squamous cell carcinoma: Although EGFR overexpression seems to be predictive of response to lapatinib or lapatinib/CRT, EGFR gene amplification was not, which is in contrast to various reports with other EGFR inhibitors in SCCHN (Cohen et al, 2005; Erjala et al, 2006; Agulnik et al, 2007; Thomas et al, 2007).