ACHE and Alzheimer disease: Multiple factors have been recognized to be implicated in the pathogenesis of AD, which provide diverse targets, including oxidative stress, acetylcholinesterase enzyme (AChE), butyrylcholinesterase (BChE), monoamine oxidase (MAO), amyloid-b peptide (Ab) aggregation, etc. [5,6,7,8,9,10], to screen drugs to treat this disease.