DICER1 and neoplasm: In the colon (Figure 1B), Dicer was still not significantly different between normal mucosa (2.870 ± 1.066) and primary tumour (2.702 ± 1.204, P = 0.250) while the Dicer mRNA expression in liver metastases (2.081 ± 1.207) was significantly decreased in comparison to that in either normal mucosa (P = 0.003) or primary tumours (P = 0.034).