The mRNA level of Dicer between primary CRCs (2.863 ± 1.137) and the corresponding normal mucosa (2.851 ± 1.040) from 162 CRC patients did not show a significant difference (P = 0.835), while Dicer mRNA in liver metastasis (1.839 ± 1.148) was obviously lower than that in either the normal mucosa or the primary tumour (P < 0.0001, Figure 1A). The gene discussed is DICER1; the disease is neoplasm.