In co-culture assays, aAPC-expanded TILs containing MART-1-specific CD8+ T cells retained the ability to recognize and respond to the HLA-matched, MART-1 expressing melanoma cells line 624, but not when stimulated with HLA-A2neg MART-1+ melanoma (938), or HLA-matched MART-1neg (OVCAR5) or HLA-A2neg MART-1neg (SKOV3) ovarian cancer cell lines (Figure 4c), indicating maintenance of anti-tumor reactivity by aAPC expanded TILs. The gene discussed is CD8A; the disease is melanoma.