CDKN2A and cancer: For example, MACC1 is a growth pathway regulator influencing angiogenesis and processes related to metastasis [15]; CDKN2A is a well-studied cell cycle regulator [12] and a known tumor suppressor whose loss results in a diminished ability to regulate growth and predisposition to cancer [11]; ITGB8 has been implicated in activities related to metastasis, including adhesion and migration [14]; and the telomerase enzyme (TERT) is linked to unlimited replication [1].