We previously described high levels of lactate (indicative of aerobic glycolysis), low concentrations of glucose (indicative of high rates of glucose consumption) and elevated expression of GLUT1 in mammary tumors from MMTV-c-ErbB2 mice and that these changes were further enhanced in tumors that arose in the bitransgenic MMTV-c-ErbB2, MMTV-myr-Akt1 mice [24]. The gene discussed is SLC2A1; the disease is breast cancer.