These results suggest that the accumulation of VLCFAs may not be the cause of the neuronal function disorders in Drosophila. On the other hand, we found that pex16 homozygotes demonstrate phenotypes that have some homology to the disorders found in Zellweger syndrome patients, including a reduced lifespan, locomotion defects, and abnormal neuronal development, with some exceptions such as infant death. The gene discussed is PEX16; the disease is Zellweger syndrome.