Even if data from animal models of T2D support the concept that local inflammation processes are essential promoters in the disease pathogenesis, further studies are required to better characterize intra-islet inflammation and to determine whether overfeeding and related obesity could exacerbate and prompt ß-cell to express cytokines and their receptors contributing thereby to defects in insulin secretion and ß-cell survival. This evidence concerns the gene INS and obesity disorder.