We found no significant differences in the proportion of IFN-γ+ cells within the IL-17-producing CD4 subset as compared to healthy subjects (22.55%±2.34% in CVID and 14.45%±1.70% in healthy, P = .0567) and no relationship between the frequencies of IFN-γ- and IL-17-producing CD4 T cells (r = −0.2504, P = .1821). This evidence concerns the gene CD4 and common variable immunodeficiency.