In our study, fluvastatin (from 0.01 μM) inhibits IL-8 release from whole blood cells of CF patients in different conditions including in unstimulated cells, those stimulated by antigens from Pseudomonas aeruginosa or, with lesser effect, by soluble antigens from Aspergillus fumigatus. The gene discussed is CXCL8; the disease is cystic fibrosis.