Thus, the subnormal sweat secretion rate in adults with GH deficiency reported in previous studies [1–4] as well as the positive correlations between circulating IGF-I levels and sweat secretion rate in these patients [1] may be specifically related to severe GH deficiency and not impaired GH-IGF-I axis per se. One explanation for the difference could be damage to the thermoregulatory centre in these patients with pituitary disease; however, parts of the GH-IGF axis seem to be present in human sweat glands [10, 24]. This evidence concerns the gene IGF1 and pituitary gland disorder.