ENO2 and Bilateral tonic-clonic seizure: When SSEPs are favourable or when SSEPs are not accessible, the presence of more than one pejorative EEG-biological-clinical criterion at day 3 should be considered sufficient to forego further treatment; these include: serum NSE > 97 ng/mL, malignant EEG pattern (burst-suppression with or without epileptiform discharge or isoelectric pattern), absence of pupillary light reflex or corneal reflex, and persistence of tonic-clonic seizures or myoclonus.