Both caspases were elevated in lung explants with emphysema following 18 h of culture with rTRAIL compared to untreated lung tissues ([Area Under the Curve (AUC) rTRAIL treated/AUC untreated*100] Casp-3 +14.1%; Casp-8 +20.7%). Here, CASP8 is linked to pulmonary emphysema.