Notably, the PI3K/Akt pathway, which is abnormally activated in many types of B-cell lymphomas, seems to participate in mTORC1 upregulation at least in a subset of these entities [22, 25, 27–29, 31–39, 41, 43–45, 47–49] (Table 1). The gene discussed is PIK3CA; the disease is B-cell non-Hodgkin lymphoma.