Although mutations in the aggrecan and versican genes (ACAN: 15q26.1 and VCAN: 5q14.2–14.3) have been linked to different connective tissue disorders (Gleghorn et al., 2005; Stattin et al., 2010; Miyamoto et al., 2005; Fig. 6), no mutations in the brevican or neurocan genes (BCAN: 1q23.1 and NCAN: 19p13.11) have been identified to date. This evidence concerns the gene NCAN and connective tissue disorder.