TARDBP and proteostasis deficiencies: Our findings revealed that in contrast to acute stress, chronic oxidative stress induced several features consistent with TDP-43 proteinopathies including loss of nuclear TDP-43, accumulation of diffuse TDP-43 in the cytosol, formation of a 35 kDa C-terminal fragment and accumulation of TDP-43 in SGs, some of which revealed ubiquitination.