However, considering only NSCLC with AC histology, the level of CD44v6 expression had no significant association with lymph node metastases or tumor stage in the study by Ramasami et al. [20] Thus, it seems reasonable to predict that tumor invasion and metastasis could be enhanced by the cell-ECM interaction in CD44-overexpressed tissue or by cell-cell interaction in CD44-deficient tissue. This evidence concerns the gene CD44 and neoplasm.