BGLAP and Graves disease: The significantly higher bone formation markers (serum bone specific alkaline phosphatase and serum osteocalcin) and bone resorption markers (Serum β-CTx, urinary calcium and urinary deoxypyridinoline) in both patients with toxic Graves' disease and toxic multinodular goiter, found in the present work, confirms the high turnover state in the skeleton of patients with hyperthyroidism.