BGLAP and Graves disease: However, there were non-significant difference in patients with Graves' disease compared to those with toxic nodular goiter, as regard bone formation markers (serum B-ALP and osteocalcin), bone resorption markers (serum β-CTx, urinary calcium/urinary creatinine, urinary DXP and urinary DXP/urinary creatinine ratio) and BMD (P > 0.05).