BRCA1 and breast cancer: BRCA1-mutant HCC1937 breast cancer cells were more sensitive to vinorelbine than BRCA1-proficient MCF7 and MDA-MB-468 cells; when docetaxel was used, HCC1937 were similarly sensitive as compared to MCF7, and less sensitive than MDA-MB-468 (MTT test). Transfection of the wild-type BRCA1 in HCC1937 cells rendered resistance to vinorelbine, but slightly increased sensitivity to docetaxel. The effect of vinorelbine was at least in part attributed to the modulation of the apoptotic response.