AG014699 (PARP inhibitor) was highly cytotoxic against BRCA2-deficient CAPAN1 pancreatic cancer cells, as determined by a clonogenic assay. AG014699 and carboplatin efficiently inhibited growth of CAPAN1-derived tumor xenografts, with the most pronounced effect while using combination of these drugs. Here, BRCA2 is linked to familial pancreatic carcinoma.