BRCA1- and BRCA2-related recurrent ovarian cancers, with at least 1 prior chemotherapy regimen, treated by high-dose (n = 33) or low-dose (n = 24) olaparib. OR in 33% and 15%; SD in 36% and 29%; median duration of response = 290 and 269 days. This evidence concerns the gene BRCA2 and ovarian carcinoma.