Tetracycline regulated inducible expression of BRCA1 in MBR62-bcl2 breast cancer cell line increased sensitivity to paclitaxel and vincristine, by did not affect the response to cisplatin, doxorubicin, cyclophosphamide, 5-fluorouracil, or bleomycin, as determined by a clonogenic assay. This evidence concerns the gene BRCA1 and breast carcinoma.