Long term outcome of high dose therapy (carboplatin, thiotepa and cyclophosphamide) is analyzed in 40 patients with metastatic breast cancer. 6 patients remained on complete remission at the time of the analysis (56+ - 150+ months); all these 6 patients demonstrated chromosomal imbalances characteristic for BRCA1-related cancers. Complete long term responders included 1 out of 2 BRCA1- and 1 out of 2 BRCA2-carriers. Here, BRCA2 is linked to cancer.