BRCA2 and pancreatic neoplasm: Increased sensitivity of BRCA2-deficient pancreatic cancer cell line CAPAN1 to mitoxantrone, etoposide and amsacrine, but not to paclitaxel, as assessed by a cell survival assay. Antisense down-regulation of BRCA2 in BRCA2-proficient pancreatic cancer cells resulted in hypersensitivity to mitoxantrone. CAPAN1 xenografted tumors showed nearly complete response to mitoxantrone and marked response to etoposide.