SNPs in genes selected in the previously identified category (ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11) have been analyzed in previous independent genetic association studies and they are a priori attractive candidates for genetic susceptibility to CRC [6,9-24]. This evidence concerns the gene IL6 and colorectal carcinoma.