Significant results for previously identified SNPs in independent cohorts regarding CRC risk were previously reported for APC [11,12], CCDN1 [13,14], IL6 and IL8 [15,16], IRS1 [17], MTHFR [18-20], PPARG [21], and VDR [22,23]. This evidence concerns the gene MTHFR and colorectal carcinoma.