Here, we report results from a case-control association study for CRC risk in the EPICOLON cohort for previously identified SNPs in ADH1C, APC, CCDN1, IL6, IL8, IRS1, MTHFR, PPARG, VDR and ARL11, and selected variants within the mucin gene family. This evidence concerns the gene MTHFR and colorectal carcinoma.