Imiquimod significantly increased the levels of serum BAFF in ITP mice (10578.43±417.54 pg/ml, P = 0.001) whereas TLR7 silencing lentivirus decreased the levels of serum BAFF in ITP mice (7258.36±359.17 pg/ml, P = 0.011). This evidence concerns the gene TLR7 and autoimmune thrombocytopenic purpura.