TLR7 and autoimmune thrombocytopenic purpura: TLR7 silencing lentivirus injection significantly increased the relative platelet counts (1.11±0.12 vs 0.84±0.09, P = 0.025) whereas imiquimod injection significantly decreased the relative platelet counts in ITP mice (0.59±0.05 vs 0.84±0.09, P = 0.034).