In the overall cohort of IBD patients, four markers were above the threshold for significance for CD: the TNFSF15 (rs4263839, P  =  7.183×10−6), NKX2-3 (rs11190140, P  =  0.003), ZNF365 (rs10761659, P  =  0.007), and PTPN2 (rs2542151, P  =  0.037). This evidence concerns the gene PTPN2 and inflammatory bowel disease.