AngII treatment significantly increased ROS in Neuro2A cells (31±11 vs. 1.0±0.5 fold, P<0.01 vs. no treatment; Figure 1D,E), while pre-infection with Ad-ACE2 significantly attenuated the AngII-induced oxidative stress (10.1±3.7 fold, P<0.05; Figure 1D,E). Here, AGT is linked to infection.