CDH1 and breast cancer: Moreover, the expression patterns of metastasis-associated molecules, such as cell adhesion molecule E-cadherin [60], matrix metalloproteinases [61], growth factors [62], [63], chemokines and their receptors [64], [65], are reported to be regulated by estrogen, leading to epithelial-to-mesenchymal-like transition and promoting breast cancer cells escape from primary site and migrate toward target tissues and organs.