Table 1A shows that high SPARC, FOXP3, CD8 and CD45RO expression in CRC tissue all independently predicted survival. Combining all four markers in a multivariate analysis (Table 1B) demonstrated, that while each of these markers had significant prognostic value on their own, used together they did not improve the prediction of survival. The combination of SPARC and FOXP3, or SPARC and CD8, however, significantly predicted survival better than using all four markers in concert, or the combination of FOXP3, CD8 and CD45RO (Table 1B). The gene discussed is SPARC; the disease is colorectal carcinoma.