Markedly increased postoperative fractional excretion of hepcidin (10-fold) in patients not developing AKI may point toward (1) relatively preserved filtration, (2) reduced or saturated reabsorption, (3) increased active secretion and (4) increased local synthesis of hepcidin along the nephron [13], or any combination of these factors. The gene discussed is HAMP; the disease is acute kidney injury.