THBS4 and cancer: Within the group of genes showing the inverse pattern (i.e., overexpression in ERG-negative cancers with a marked fold-increase in ERG-positive tumors), noteworthy hits were AMACR (lipid and amino-acid metabolic enzyme), PCA3 (prostate cancer antigen), THBS4 (a membrane protein involved in various processes) and GAL (signaling molecule) (Figure 2D).