CRISP3 and Familial prostate cancer: Our data confirms the upregulation of CRISP3 in prostate cancer, but further shows that CRISP3 is under the direct control of the transcription factor ERG. A strong correlation between ERG and CRISP3 expression was seen in both our test and validation series using different mRNA-based methodologies, and also by the external validation using the publicly available expression data from Setlur et al. (GSE8402) [17].