While this analysis will have to be repeated in larger sample sets, our results are consistent with a model in which disruption of YY1 binding at the common risk allele of rs378854 is associated with transcriptional activation of PVT1. We also examined expression of miRNAs embedded within the PVT1 locus (hsa-mir-1204, hsa-mir-1205, hsa-mir-1206, hsa-mir-1207-3p and hsa-mir-1207-5p), but the expression was found to be very low or undetectable in both normal and tumour prostate samples and no clear pattern of association emerged (data not shown). The gene discussed is PVT1; the disease is neoplasm.