LZTR1 and infection: Indeed, while propagation of JFH1/Jc1 NS2 and JFH1/Jc1 TM1—NS2 HCVcc progressed very slowly, upon infection at low multiplicities of infection (MOIs of 0.01), the JFH1/Jc1 TM1,2—NS2 and JFH1/Jc1 TM2—NS2 viruses displayed much faster propagation rates, in a manner correlated with the extent of core-ER localization.