POMC is the precursor of hypothalamic neuropeptide, α-melanocyte-stimulating hormone (α-MSH), which is an important hypothalamic regulator of feeding and energy balance, and mutation of POMC gene is sufficient to cause severe obesity and diabetes in both rodents [34] and humans [35],[36]. This evidence concerns the gene STAMBP and obesity due to melanocortin 4 receptor deficiency.