ESR1 and neoplasm: BPA phosphorylates the Ser118 site of ER-α by activating the GPR30 and EFGR-ERK pathways. Mitogen-activated protein kinase (MAPK)-mediated phosphorylation in Ser118 site of ER-α has been suggested to enhance the tumor growth induced by MAPK/ER cross-talk (Atanaskova et al. 2002).