Hence, data from the present study indicate that a complex interplay between ER-α and GPR30 contributes to low concentrations of BPA activity in GC-1 cells by activating EGFR-ERK transduction pathways, similar results for atrazine in ovarian cancer cells (Albanito et al. 2008a; Bunone et al. 1996). This evidence concerns the gene ESR1 and ovarian carcinoma.