Studies from our own laboratory have shown that Tau in striata of PD patients is hyperphosphorylated at Ser202, Ser262 and Ser396/404, where increases of 23, 34 and 81% were observed in PD compared to control, non-diseased striata [35], testifying to the pathophysiological relevance of these sites. The gene discussed is MAPT; the disease is Parkinson disease.