However in a linear regression analysis with CIMT as the dependent variable, weak associations were found between CIMT and patient age (R = 0.30, p = 0.0001), systolic blood pressure (R = 0.22, p = 0.003), vibratory perception threshold (R = 0.18, p = 0.016), heart rate variability (-R = 0.15, p = 0.053), presence of retinopathy (R = 0.17, p = 0.019, toe-brachial index (R=-0.22, p = 0.002), P-NT-proBNP (R = 0.19, p = 0.009) and CCS (R = 0.19, p = 0.009). This evidence concerns the gene NPPB and retinal disorder.