POMC and pituitary tumor: Pharmacological reduction of glucocorticoid activity can be achieved via several mechanisms of action, including neuromodulatory compounds which reduce corticotropin (ACTH) release from pituitary tumors, steroidogenesis inhibitors which reduce cortisol levels by adrenolytic activity and/or direct enzymatic inhibition, and finally glucocorticoid receptor (GR) antagonists which block cortisol action at its receptor [6, 7].