IGHG3 and malaria: Several studies have demonstrated that the sub-classes IgG1 and IgG3 (called cytophilic classes due to their high capacity to induce immune cells to respond) are the most prominent classes among individuals living in malaria endemic areas that have achieved partial immunity [13] and are also the sub-classes that elicit phagocytosis in monocytes and macrophages [3], [14], [15].