Abnormally high levels of BORIS transcripts are present in a variety of human tumours and cancer-derived cell lines and, in some, increased expression has been linked to promoter-specific demethylation and de-repression of co-expressed cancer-testis genes [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]. The gene discussed is CTCFL; the disease is cancer.