Further studies in larger series of patients are warranted to elucidate this question and determine the specific role of those cancer associated genes (INPP5A, CDX1, MB, CAMK2A, APOL6 vs. VPS53, FAM57A, GEMIN4, SFRS13, ELP2P, GLOD4, CSF2RA and IL3RA), differentially altered in both groups of tumors. The gene discussed is IL3RA; the disease is cancer.