HIF1A and neoplasm: We then asked wether Omomyc interacted with Hypoxia-inducible factor 1-alpha (Hif-1α), a protein that functions as a master transcriptional regulator of the adaptive response to hypoxia, plays an essential role in tumor angiogenesis and shows a considerable interplay with Myc in the regulation of multiple glycolytic genes [23]–[25].