8-Br-cAMP induced a rapid fluorescence increase in Suit-2 cells, that was almost completely inhibited by treatment with the CFTR inhibitor CFTR (inh)-172 [18], while in CFPAC-1, a pancreatic adenocarcinoma cell line derived from a patient affected by CF (F508del/F508del genotype) cAMP analog was not able to induce fluorescence changes (Figure 3A). Here, CFTR is linked to pancreatic adenocarcinoma.