For instance, as the variables we analyzed targets myeloid cells whose involvement in the pathogenesis of CF is becoming increasingly recognized in the field [9], [39], [40], this approach might represent a valuable marker of the therapeutic effects of CFTR-targeted drugs in CF patients and they might be used to test the efficacy of any drugs targeting mutations affecting CFTR expression (by western blot) or function (by cell membrane depolarization assay), such as the ones currently under clinical evaluation [41]. The gene discussed is CFTR; the disease is cystic fibrosis.