GATA6 and familial pancreatic carcinoma: In pancreatic cancer tissues, GATA6 overexpression was significantly correlated with nuclear accumulation of ß-catenin protein (8/12 PDACs with GATA6 overexpression showing ß-catenin nuclear accumulation versus 3/20 without GATA6 overexpression, p = 0.004) (Figure 4E).