Within 3.5 years of HAART (highly active antiretroviral therapy) initiation 11.3% of subjects developed AIDS and determinants of AIDS was a CD4 cell count of < 200cells/microl (relative hazard = 2.25 95% CI = 1.13, 4.49). An increase in CD4 counts of 50microlit. Immediately after HAART initiation also improved prognosis (RH = 0.34, 95% CI = 0.16, 0.71). This evidence concerns the gene CD4 and AIDS.