The TGFBR1 gene located in chromosomal region 9q22 was also incorporated in our study, and SNPs within this gene included rs11466445, a polymorphic 9-bp deletion with controversial results regarding its association with CRC risk (Kaklamani et al, 2003; Skoglund et al, 2007). Here, TGFBR1 is linked to colorectal carcinoma.