However, some of the SNPs in region 3q22 showed interesting results in the joint analysis combining both cohorts (1361 CRC cases and 1342 controls), especially rs1444601 in TOPBP1 and rs13088006 in CDV3, which maintained statistical significance with an unadjusted P-value in all phases. This evidence concerns the gene TOPBP1 and colorectal carcinoma.