To determine K-Ras and B-raf status in adenomas developing in Apcmin/+ mice, we performed K-ras pyrosequencing for known mutations in codons 12, 13 and 61 and allelic discrimination assays for B-raf V600E, which failed to identify mutations in genomic DNA from 30 individual Apcmin/+ colon adenomas harvested from 29 mice (data not shown). Here, KRAS is linked to adenoma.