PARP1 and Familial prostate cancer: We did not observe main effects or notable interactions for XRCC1 R399Q (rs25487), PARP1 [poly (ADP-ribose) polymerase 1] V762A (rs1136410), or OGG1 (8-oxoguanine DNA glycosylase) S326C (rs1052133), although some previous studies have observed phenotypic changes and altered prostate cancer susceptibility with genetic variation at these loci (Park et al. 2009).