TAC1 and Headache: In the study from Boot et al. [13] adverse events were reported as transient self-limiting bronchospasm starting within 12 minutes after drug inhalation (8 patients under NK-1/NK-2 antagonist and 4 patients under placebo), headache (5 patients under NK-1/NK-2 antagonist and 3 patients under placebo), and self-limiting dyspneia (2 patients under NK-1/NK-2 antagonist and 5 patients under placebo).