NPHS1 and primary membranoproliferative glomerulonephritis: Furness et al. [107], Huh et al. [108], Srivastava et al. [109], Wang et al. [110], and Doublier et al. [111] reported a downregulation in nephrin expression in patients with focal segmental glomerular sclerosis, MPGN and membranous nephropathy (MN), whereas, as reported by Patrakka et al. [112], Guan et al. [113], and Hingorani et al. [114], no significant changes were seen in expression of nephrin at all.