NOTCH1 and cancer: On the other hand, 107 of the genes on the recurrent regions overlapped with V2 and they include TACC3, ECT2, CDC6, NOTCH1, and PIK3CA etc. Here we found a molecular mechanism that linked TACC3 and TPX2 through AURKA. TACC3, located on an amplified region on 4p16, recently emerged as an important gene in the stabilization of the mitotic spindle[41], and is up-regulated in several cancer cell lines including thyroid and lung cancers[42-44].