E2F1 and cancer: This is further supported by the fact that the inferred key drivers include not only known breast cancer metastasis genes (MTDH[13] and ERBB2[49]) but also known cancer cell cycle genes such as TPX2, AURKA, E2F1 and BIRC5. As shown in Figure 6, these known cell cycle and metastasis genes interact with each other and with many other drivers to co-regulate the genes on the AARs.