At the same time it should be mentioned that many groups including us have not observed infiltration of autoreactive T cells (presumed Th1 response that likely occurred in AN1792 vaccinated patients) in the brains after immunizations of APP/Tg or wild-type mice with the original Schenk et al. protocol [2] or with other Aβ vaccines (unless pertussis toxin widely used to induce brain T cell penetration in experimental autoimmune encephalomyelitis have been co-administered [78]). This evidence concerns the gene APP and experimental autoimmune encephalomyelitis.