Nevertheless, tPA antigen, PAI-1 antigen, PAI activity and tPA/PAI-1 complex levels were significantly higher in ischemic stroke patients in comparison with a control group, but no differences were found regardless of stroke etiology except for lower levels of PAI-1 antigen in cardioembolic stroke in a case-control clinical study [63]. The gene discussed is PLAT; the disease is cardioembolic stroke.